Life Extension, Two-Per-Day Multivitamin, 120 Tablets vs Pure Encapsulations, O.N.E.™ Multivitamin, 60 Capsules: Multivitamin Comparison
Life Extension Two-Per-Day vs Pure Encapsulations O.N.E.: High-Potency Value or Once-Daily CoQ10 Focus?
Life Extension Two-Per-Day vs Pure Encapsulations O.N.E. — Forms, Chelates & Antioxidant Strategy
Two Per Day
A high-potency, “two-tablets-per-day” workhorse built around aggressive B-vitamin dosing and a broad antioxidant add-on panel. Strengths: mixed-but-premium mineral strategy (zinc includes L-OptiZinc; selenium includes SelenoExcell; chromium uses Crominex 3+), plus extras like Bio-Quercetin phytosome, lutein/zeaxanthin from marigold, and LycoBeads lycopene. Tradeoffs: magnesium is present but as magnesium oxide (low-form), and the very high B-complex can be “too much” for sensitive users. Best fit: value-driven users who want maximum potency + extra polyphenols/carotenoids and are okay with 2-per-day dosing.
O.N.E Multivitamin
A “professional / hypoallergenic” once-daily formula that leans into form-transparency and targeted antioxidant support rather than maximal dosing. Standout: 50 mg CoQ10 with a sustained-release MicroActive cyclodextrin complex, plus Metafolin (L-5-MTHF) and explicitly stated activated B-vitamin proportions—rare label clarity. Tradeoffs: mineral panel is simpler; zinc is citrate (not a premium chelate), and magnesium is absent—so most users will still add magnesium separately. Best fit: people who want a cleaner, simpler 1-capsule routine, prioritize CoQ10 inclusion, and prefer “active-form” labeling over mega-dose intensity.
Bottom line: Choose Life Extension Two-Per-Day if you want the best price-per-serving with high-potency Bs and a broader polyphenol/carotenoid add-on panel; choose Pure Encapsulations O.N.E. if you want once-daily simplicity, hypoallergenic positioning, and built-in sustained-release CoQ10 with unusually transparent activated B-vitamin labeling.
Ingredient Breakdown
 price category: ⚖️ Standard index bioavailability: |  price category: ⚖️ Standard index bioavailability: | ||
|---|---|---|---|
| Usage & Audience | |||
Serving Size | 2 Tablets | 1 Capsules | |
Servings Per Container | 60 | 60 | |
Audience | - | Adults 18+ yrs | |
| Pricing | |||
Price |
$18.38
Check price
|
$45.20
Check price
| |
Price Per Serving | $0.31 | $0.75 | |
Price Updated At | 11/30/2025 (Iherb US) | 11/30/2025 (Iherb US) | |
Chelated Minerals Overview Details below | |||
| Minerals total | 8 | 7 | |
Pure chelates | 2 | 3 | |
Mixed chelates | 2 | 0 | |
Non-chelated | 4 | 4 | |
| Contains chelate (any) | 4 | 3 | |
| Chelate coverage | 50% | 43% | |
| Purity within chelated | 25% | 43% | |
| Base Ingredients | |||
Bioavailability Legend: ?SuperiorHighUp. MediumMediumVariableLow-MidLowVery low | |||
| Ingredient | Life Extension Two Per Day Amount Per Serving% Daily ValueBio- availability Level | Pure Encapsulations O.N.E Multivitamin Amount Per Serving% Daily ValueBio- availability Level | |
Vitamin A | 1500 mcg^ 167% Up. Medium | 1,125 mcg 125% Up. Medium | |
Vitamin C | 470 mg 522% High | 180 mg 200% High | |
Vitamin D | 50 mcg 250% High | 50 mcg (2,000 IU) 250% High | |
Vitamin B1 | 75 mg 6250% High | 3 mg 250% High | |
Vitamin B2 | 50 mg 3846% Up. Medium | 3 mg 231% Up. Medium | |
Vitamin B3 | 50 mg° 313% High | 20 mg 125% High | |
Vitamin B6 | 75 mg 4412% Up. Medium | 4 mg 235% Up. Medium | |
Folate | 680 mcg° 170% High | 667 mcg DFE (400 mcg L-5-MTHF) 167% Superior | |
Vitamin B12 | 300 mcg 12500% High | 500 mcg 20,833% High | |
Biotin | 300 mcg 1000% High | 300 mcg 1,000% High | |
Pantothenic acid | 50 mg 1000% High | 10 mg 200% High | |
Iodine | 150 mcg 100% High | 150 mcg 100% High | |
Zinc | 25 mg 227% High | 25 mg 227% Medium | |
Magnesium | 100 mg 24% Low | Ø Absent | |
Selenium | 200 mcg 364% High | 70 mcg 127% High | |
Manganese | 2 mg 87% Up. Medium | 2 mg 87% High | |
Chromium | 200 mcg 571% Superior | 200 mcg 571% High | |
Molybdenum | 100 mcg 222% High | 75 mcg 167% High | |
| Extra Ingredients | |||
Boron | 3 mg ** High | 1 mg * High | |
Inositol | 50 mg ** High | 25 mg * High | |
Alpha lipoic acid | 25 mg ** High | 50 mg * High | |
Coenzyme Q10 | Ø Absent | 50 mg * Superior | |
Vitamin E | 67 mg 447% High | 20 mg 134% Up. Medium | |
Quercetin | 15 mg ** Superior | Ø Absent | |
Lutein | Ø Absent | 3 mg * High | |
Marigold extract | 11.12 mg ** High | Ø Absent | |
Zeaxanthin | Ø Absent | 500 mcg * Up. Medium | |
Apigenin | 5 mg ** Low | Ø Absent | |
Lycopene | 1 mg ** High | 500 mcg * Medium | |
| Other Ingredients | |||
Other Ingredients | Ø Absent | ||
| Symbol Decoding | |||
Symbol Decoding | |||